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WP3: Stability, release and functionality – University of Copenhagen

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WP3: Stability, release and functionality

In WP3 five different methodologies will be explored for the assessment of material stability, content release and functionality at the intestinal mucosa.

Projects

WP3.1: Characterization of materials and their effect on enzyme interactions by Raman spectroscopy (Sofia Prazeres and Diogo Quintela, Alcalá University, Spain)

Objectives
Characterization of materials and their effect on enzyme structure.

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WP3.2: Application of advanced GIT methodology for product validation and assessment of product stability (Tomasz Cieplak, University of Copenhagen, Denmark)

Objectives

Development of methods/protocols for high throughput in vitro gastrointestinal tract (GIT) passage simulation.

Read more here.

WP3.3: Establishment of a stable multi-species probiotic consortium though hydrogel encapsulation techniques (Racha el Hage, University of Ghent, Belgium)

Objectives

Composition of a mcrobial consortium whose members occupy crucial functional niches in the human gut. Emphasis is placed on obtaining benchmark values for glycan degradation and representative fermentation profiles. Also, evaluation of the capability of hydrogels to protect the composed microbial consortium across upper digestive tract passage.

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WP3.4: Material stbility during gastrointestinal transit and at the gut mucosa (Maryam Eshrati, University of Heidelberg, Germany)

Objectives
  • Impact of encapsulation method and size of adhesion of tailor-made capsules onto intestinal epithelial layers.
  • Correlation between adhesion strength and probiotic functions.

WP3.5: Enzyme and probiotic stability and functionality assesment at the gut mucosa (Davide Gottardi, ProDigest AB, Belgium)

Objectives
  • Evaluation of the ultimate success of the administration of encapsulated probiotics, depending on their release in a functional state during intestinal passage.
  • Evaluation of the capability of encapsulation methods to protect probiotics in the upper intestine, resulting in optimal functionality in the lower intestine, both in the gut lumen and especially at the site of host-microbe interactions (gut mucosa).

Read more here.